Bibliography

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2022

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Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

AlbaGonzalez-Franquesa,  PauGama-Perez, Marta Kulis, Karolina Szczepanowska, Norma Dahdah, Sonia Moreno-Gomez, Ana Latorre-Pellicer, Rebeca Fernández-Ruiz, Antoni Aguilar-Mogas, Anne Hoffman, Erika Monelli, Sara Samino, Joan Miró-Blanch, Gregor Oemer, XavierDuran, Estrella Sanchez-Rebordelo, Marc Schneebergerg, Merce Obach, (… ) Pablo M.Garcia-Roves.

Redox Biology Volume 54, August 2022, 102353.  https://doi.org/10.1016/j.redox.2022.102353

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2021

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Effects of Lifestyle Intervention in Tissue-Specific Lipidomic Profile of Formerly Obese Mice

Dahdah N, Gonzalez-Franquesa A, Samino S, Gama-Perez P,  Herrero L, Perales JC, Yanes O, Malagón MM, García-Rovés PM.

Int. J. Mol. Sci. 2021, 22(7), 3694; https://doi.org/10.3390/ijms22073694 - 01 Apr 2021

 

NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression.

Sánchez-de-Diego C, Pedrazza L, Pimenta-Lopes C, Martinez-Martinez A, Dahdah N, Valer JA, Garcia-Roves P, Rosa JL, Ventura F.

Redox Biology. 2021 Apr;40:101845. doi: 10.1016/j.redox.2020.101845. Epub 2020 Dec 24.

PMID: 33373776

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PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner.

Hyroššová P, Aragó M, Moreno-Felici J, Fu X, Mendez-Lucas A, García-Rovés PM, Burgess S, Figueras A, Viñals F, Perales JC.

Cancer Metab. 2021 Jan 7;9(1):1. doi: 10.1186/s40170-020-00236-3.PMID: 33413684 Free PMC article.

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2020

 

Editorial: Mitochondrial Proteomics: Understanding Mitochondria Function and Dysfunction Through the Characterization of Their Proteome.

Ferri A, Garcia-Roves PM, Pieroni L.

Front Cell Dev Biol. 2020 Dec 10;8:608753. doi: 10.3389/fcell.2020.608753. eCollection 2020.PMID: 33363170 Free PMC article. 

 

Phosphoenolpyruvate from Glycolysis and PEPCK Regulate Cancer Cell Fate by Altering Cytosolic Ca2.

Moreno-Felici J, Hyroššová P, Aragó M, Rodríguez-Arévalo S, García-Rovés PM, Escolano C, Perales JC.

Cells. 2019 Dec 19;9(1):18. doi: 10.3390/cells9010018.PMID: 31861674 Free PMC article.

 

Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M.

Aragó M, Moreno-Felici J, Abás S, Rodríguez-Arévalo S, Hyroššová P, Figueras A, Viñals F, Pérez B, Loza MI, Brea J, Latorre P, Carrodeguas JA, García-Rovés PM, Galdeano C, Ginex T, Luque FJ, Escolano C, Perales JC.

Biomed Pharmacother. 2020 Jan;121:109601. doi: 10.1016/j.biopha.2019.109601. Epub 2019 Nov 15.PMID: 31739159 

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2019

 

Dietary Calanus oil recovers metabolic flexibility and rescues postischemic cardiac function in obese female mice.

Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS.

Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H290-H299. doi: 10.1152/ajpheart.00191.2019. Epub 2019 May 24.PMID: 31125256 

 

Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program.

Sánchez-de-Diego C, Artigas N, Pimenta-Lopes C, Valer JA, Torrejon B, Gama-Pérez P, Villena JA, Garcia-Roves PM, Rosa JL, Ventura F.

iScience. 2019 May 31;15:79-94. doi: 10.1016/j.isci.2019.04.015. Epub 2019 Apr 12.PMID: 31039455 Free PMC article.

 

Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue.

Pardo R, Vilà M, Cervela L, de Marco M, Gama-Pérez P, González-Franquesa A, Statuto L, Vilallonga R, Simó R, Garcia-Roves PM, Villena JA.

FASEB J. 2019 Feb;33(2):2343-2358. doi: 10.1096/fj.201800310R. Epub 2018 Oct 2.PMID: 30277821

 

Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells.

Ejarque M, Ceperuelo-Mallafré V, Serena C, Maymo-Masip E, Duran X, Díaz-Ramos A, Millan-Scheiding M, Núñez-Álvarez Y, Núñez-Roa C, Gama P, Garcia-Roves PM, Peinado MA, Gimble JM, Zorzano A, Vendrell J, Fernández-Veledo S.

Int J Obes (Lond). 2019 Jun;43(6):1256-1268. doi: 10.1038/s41366-018-0219-6. Epub 2018 Sep 27.PMID: 30262812 Free PMC article.

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2017

 

Correction to: the disruption of mitochondrial axonal transport is an early event in neuroinflammation.

Errea O, Moreno B, Gonzalez-Franquesa A, Garcia-Roves PM, Villoslada P.

J Neuroinflammation. 2017 Oct 23;14(1):206. doi: 10.1186/s12974-017-0979-2.PMID: 29061147 Free PMC article. 

 

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.

Posavec Marjanović M, Hurtado-Bagès S, Lassi M, Valero V, Malinverni R, Delage H, Navarro M, Corujo D, Guberovic I, Douet J, Gama-Perez P, Garcia-Roves PM, Ahel I, Ladurner AG, Yanes O, Bouvet P, Suelves M, Teperino R, Pospisilik JA, Buschbeck M.

Nat Struct Mol Biol. 2017 Nov;24(11):902-910. doi: 10.1038/nsmb.3481. Epub 2017 Oct 9.PMID: 28991266 Free PMC article.

 

Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M.

Cell Metab. 2017 Jun 6;25(6):1390-1399.e6. doi: 10.1016/j.cmet.2017.05.010.PMID: 28591639 Free article

 

Editorial:Dissecting the Role of Mitochondria in the Pathophysiology of Type-2 Diabetes and Obesity: Novel Concepts and Challenges.

Claret M, Garcia-Roves PM.

Curr Diabetes Rev. 2017;13(4):337. doi: 10.2174/157339981304170725150725.PMID: 26923542 

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2016

 

Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice.

Ejaz A, Martinez-Guino L, Goldfine AB, Ribas-Aulinas F, De Nigris V, Ribó S, Gonzalez-Franquesa A, Garcia-Roves PM, Li E, Dreyfuss JM, Gall W, Kim JK, Bottiglieri T, Villarroya F, Gerszten RE, Patti ME, Lerin C.

Diabetes. 2016 Apr;65(4):902-12. doi: 10.2337/db15-1094. Epub 2016 Feb 8.PMID: 26858359 Free PMC article.

 

Adipose tissue glycogen accumulation is associated with obesity-linked inflammation in humans.

Ceperuelo-Mallafré V, Ejarque M, Serena C, Duran X, Montori-Grau M, Rodríguez MA, Yanes O, Núñez-Roa C, Roche K, Puthanveetil P, Garrido-Sánchez L, Saez E, Tinahones FJ, Garcia-Roves PM, Gómez-Foix AM, Saltiel AR, Vendrell J, Fernández-Veledo S.

Mol Metab. 2015 Oct 16;5(1):5-18. doi: 10.1016/j.molmet.2015.10.001. eCollection 2016 Jan.PMID: 26844203 Free PMC article.

 

Emerging Concepts in Diabetes: Mitochondrial Dynamics and Glucose Homeostasis.

Gómez-Valadés AG, Gonzalez-Franquesa A, Gama-Perez P, Claret M, Garcia-Roves PM.

Curr Diabetes Rev. 2017;13(4):370-385. doi: 10.2174/1573399812666151012115229.PMID: 26456359 Review.

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2015

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The disruption of mitochondrial axonal transport is an early event in neuroinflammation.

Errea O, Moreno B, Gonzalez-Franquesa A, Garcia-Roves PM, Villoslada P.

J Neuroinflammation. 2015 Aug 28;12:152. doi: 10.1186/s12974-015-0375-8.PMID: 26310930 Free PMC article.

 

Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis.

Schneeberger M, Gómez-Valadés AG, Altirriba J, Sebastián D, Ramírez S, Garcia A, Esteban Y, Drougard A, Ferrés-Coy A, Bortolozzi A, Garcia-Roves PM, Jones JG, Manadas B, Zorzano A, Gomis R, Claret M.

Cell Rep. 2015 Jul 21;12(3):361-70. doi: 10.1016/j.celrep.2015.06.041. Epub 2015 Jul 9.PMID: 26166568 Free article.

 

High-Resolution Respirometry for Mitochondrial Characterization of Ex Vivo Mouse Tissues.

Cantó C, Garcia-Roves PM.

Curr Protoc Mouse Biol. 2015 Jun 1;5(2):135-153. doi: 10.1002/9780470942390.mo140061.PMID: 26069081

 

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function.

Boutant M, Joffraud M, Kulkarni SS, García-Casarrubios E, García-Roves PM, Ratajczak J, Fernández-Marcos PJ, Valverde AM, Serrano M, Cantó C.

Mol Metab. 2014 Dec 18;4(2):118-31. doi: 10.1016/j.molmet.2014.12.008. eCollection 2015 Feb.PMID: 25685699 Free PMC article.

 

Circulating miR-192 and miR-193b are markers of prediabetes and are modulated by an exercise intervention.

Párrizas M, Brugnara L, Esteban Y, González-Franquesa A, Canivell S, Murillo S, Gordillo-Bastidas E, Cussó R, Cadefau JA, García-Roves PM, Servitja JM, Novials A.

J Clin Endocrinol Metab. 2015 Mar;100(3):E407-15. doi: 10.1210/jc.2014-2574. Epub 2014 Dec 22.PMID: 25532038 Clinical Trial.

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2014

 

Nutrient intake and food habits of soccer players: analyzing the correlates of eating practice.

García-Rovés PM, García-Zapico P, Patterson AM, Iglesias-Gutiérrez E.

Nutrients. 2014 Jul 18;6(7):2697-717. doi: 10.3390/nu6072697.PMID: 25045939 Free PMC article. Review.

 

Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass.

Fernandez-Ruiz R, Vieira E, Garcia-Roves PM, Gomis R.

PLoS One. 2014 Feb 28;9(2):e90344. doi: 10.1371/journal.pone.0090344. eCollection 2014.PMID: 24587334 Free PMC article.

 

Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice.

Zachariah Tom R, Garcia-Roves PM, Sjögren RJ, Jiang LQ, Holmström MH, Deshmukh AS, Vieira E, Chibalin AV, Björnholm M, Zierath JR.

Diabetes. 2014 May;63(5):1560-71. doi: 10.2337/db13-0670. Epub 2014 Jan 31.PMID: 24487023 Free article.

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2013

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Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.

Schneeberger M, Dietrich MO, Sebastián D, Imbernón M, Castaño C, Garcia A, Esteban Y, Gonzalez-Franquesa A, Rodríguez IC, Bortolozzi A, Garcia-Roves PM, Gomis R, Nogueiras R, Horvath TL, Zorzano A, Claret M.

Cell. 2013 Sep 26;155(1):172-87. doi: 10.1016/j.cell.2013.09.003.PMID: 24074867 Free PMC article.

 

Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: cause or consequence?

García-Ruiz C, Baulies A, Mari M, García-Rovés PM, Fernandez-Checa JC.

Free Radic Res. 2013 Nov;47(11):854-68. doi: 10.3109/10715762.2013.830717. Epub 2013 Oct 4.PMID: 23915028 Review.

 

Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice.

Holmström MH, Tom RZ, Björnholm M, Garcia-Roves PM, Zierath JR.

Metabolism. 2013 Sep;62(9):1258-67. doi: 10.1016/j.metabol.2013.04.001. Epub 2013 May 8.PMID: 23664724

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Expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight.

Ka S, Markljung E, Ring H, Albert FW, Harun-Or-Rashid M, Wahlberg P, Garcia-Roves PM, Zierath JR, Denbow DM, Pääbo S, Siegel PB, Andersson L, Hallböök F.

Physiol Genomics. 2013 May 1;45(9):367-76. doi: 10.1152/physiolgenomics.00078.2012. Epub 2013 Mar 19.PMID: 23512741

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2012

 

Is there a relationship between the playing position of soccer players and their food and macronutrient intake?

Iglesias-Gutiérrez E, García A, García-Zapico P, Pérez-Landaluce J, Patterson AM, García-Rovés PM.

Appl Physiol Nutr Metab. 2012 Apr;37(2):225-32. doi: 10.1139/h11-152. Epub 2012 Mar 1.PMID: 22380725

 

Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes.

Holmström MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM.

Am J Physiol Endocrinol Metab. 2012 Mar 15;302(6):E731-9. doi: 10.1152/ajpendo.00159.2011. Epub 2012 Jan 17.PMID: 22252943 

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2011

 

Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse.

Lindfors C, Nilsson IA, Garcia-Roves PM, Zuberi AR, Karimi M, Donahue LR, Roopenian DC, Mulder J, Uhlén M, Ekström TJ, Davisson MT, Hökfelt TG, Schalling M, Johansen JE.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18108-13. doi: 10.1073/pnas.1114863108. Epub 2011 Oct 24.PMID: 22025706 Free PMC article.

 

Increased hepatic insulin sensitivity in mice lacking inhibitory leptin receptor signals.

Tom RZ, Sjögren RJ, Vieira E, Glund S, Iglesias-Gutiérrez E, Garcia-Roves PM, Myers MG Jr, Björnholm M.

Endocrinology. 2011 Jun;152(6):2237-46. doi: 10.1210/en.2010-0040. Epub 2011 Apr 26.PMID: 21521753 Free article.

 

Laforin, a dual specificity phosphatase involved in Lafora disease, regulates insulin response and whole-body energy balance in mice.

Vernia S, Heredia M, Criado O, Rodriguez de Cordoba S, Garcia-Roves PM, Cansell C, Denis R, Luquet S, Foufelle F, Ferre P, Sanz P.

Hum Mol Genet. 2011 Jul 1;20(13):2571-84. doi: 10.1093/hmg/ddr157. Epub 2011 Apr 14.PMID: 21493628

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2010

 

Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle.

Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ.

J Physiol. 2010 May 15;588(Pt 10):1779-90. doi: 10.1113/jphysiol.2010.188011. Epub 2010 Mar 22.PMID: 20308248 Free PMC article.

 

Adenosine A(3) receptors regulate heart rate, motor activity and body temperature.

Yang JN, Wang Y, Garcia-Roves PM, Björnholm M, Fredholm BB.

Acta Physiol (Oxf). 2010 Jun;199(2):221-30. doi: 10.1111/j.1748-1716.2010.02091.x. Epub 2010 Feb 1.PMID: 20121716 Free PMC article.

 

Spatial insulin signalling in isolated skeletal muscle preparations.

Sogaard P, Szekeres F, Garcia-Roves PM, Larsson D, Chibalin AV, Zierath JR.

J Cell Biochem​. 2010 Apr 1;109(5):943-9. doi: 10.1002/jcb.22470.

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Exercise-beyond skeletal muscle energy metabolism.

Garcia-Roves PM.

J Appl Physiol (1985). 2010 Jan;108(1):224-4; author reply 226. doi: 10.1152/japplphysiol.01233.2009.PMID: 20066763 Free article. .

 

Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.

Jiang LQ, Garcia-Roves PM, de Castro Barbosa T, Zierath JR.

Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E8-E16. doi: 10.1152/ajpendo.00403.2009. Epub 2009 Oct 27.PMID: 19861587 Free article.

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2008

 

Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle.

Garcia-Roves PM, Osler ME, Holmström MH, Zierath JR.

J Biol Chem. 2008 Dec 19;283(51):35724-34. doi: 10.1074/jbc.M805078200. Epub 2008 Oct 6.PMID: 18838377 Free article.

 

Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle.

Vieira E, Nilsson EC, Nerstedt A, Ormestad M, Long YC, Garcia-Roves PM, Zierath JR, Mahlapuu M.

Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1032-7. doi: 10.1152/ajpendo.90510.2008. Epub 2008 Aug 26.PMID: 18728219 Free article.

 

Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle.

Bouzakri K, Austin R, Rune A, Lassman ME, Garcia-Roves PM, Berger JP, Krook A, Chibalin AV, Zhang BB, Zierath JR.

Diabetes. 2008 Jun;57(6):1508-16. doi: 10.2337/db07-0583. Epub 2008 Feb 26.PMID: 18314420 Free article.

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2007

 

Food preferences do not influence adolescent high-level athletes' dietary intake.

Iglesias-Gutiérrez E, García-Rovés PM, García A, Patterson AM.

Appetite. 2008 Mar-May;50(2-3):536-43. doi: 10.1016/j.appet.2007.11.003. Epub 2007 Nov 17.PMID: 18155807

 

Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.

Krämer DK, Al-Khalili L, Guigas B, Leng Y, Garcia-Roves PM, Krook A.

J Biol Chem. 2007 Jul 6;282(27):19313-20. doi: 10.1074/jbc.M702329200. Epub 2007 May 11.PMID: 17500064 Free article. Clinical Trial.

 

Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression.

Long YC, Glund S, Garcia-Roves PM, Zierath JR.

J Biol Chem. 2007 Jan 19;282(3):1607-14. doi: 10.1074/jbc.M609208200. Epub 2006 Nov 15.PMID: 17107952 Free article.

 

Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression.

Wright DC, Han DH, Garcia-Roves PM, Geiger PC, Jones TE, Holloszy JO.

J Biol Chem. 2007 Jan 5;282(1):194-9. doi: 10.1074/jbc.M606116200. Epub 2006 Nov 12.PMID: 17099248 Free article.

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2006

 

Role of calcineurin in exercise-induced mitochondrial biogenesis.

Garcia-Roves PM, Huss J, Holloszy JO.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1172-9. doi: 10.1152/ajpendo.00633.2005. Epub 2006 Jan 10.PMID: 16403773 Free article.

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2005

 

Food habits and nutritional status assessment of adolescent soccer players. A necessary and accurate approach.

Iglesias-Gutiérrez E, García-Rovés PM, Rodríguez C, Braga S, García-Zapico P, Patterson AM.

Can J Appl Physiol. 2005 Feb;30(1):18-32. doi: 10.1139/h05-102.PMID: 15855680

 

Calcineurin does not mediate exercise-induced increase in muscle GLUT4.

Garcia-Roves PM, Jones TE, Otani K, Han DH, Holloszy JO.

Diabetes. 2005 Mar;54(3):624-8. doi: 10.2337/diabetes.54.3.624.PMID: 15734836 Free article.

 

2004

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Calpain system regulates muscle mass and glucose transporter GLUT4 turnover.

Otani K, Han DH, Ford EL, Garcia-Roves PM, Ye H, Horikawa Y, Bell GI, Holloszy JO, Polonsky KS.

J Biol Chem. 2004 May 14;279(20):20915-20. doi: 10.1074/jbc.M400213200. Epub 2004 Mar 9.PMID: 15014085 Free article.

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2003

 

Prevention of glycogen supercompensation prolongs the increase in muscle GLUT4 after exercise.

Garcia-Roves PM, Han DH, Song Z, Jones TE, Hucker KA, Holloszy JO.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E729-36. doi: 10.1152/ajpendo.00216.2003. Epub 2003 Jun 10.PMID: 12799316 Free article.

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2000

 

Comparison of dietary intake and eating behavior of professional road cyclists during training and competition.

García-Rovés PM, Terrados N, Fernández S, Patterson AM.

Int J Sport Nutr Exerc Metab. 2000 Mar;10(1):82-98. doi: 10.1123/ijsnem.10.1.82.PMID: 10939878

 

Eating pattern and nutritional status of international elite flatwater paddlers.

Garciá-Rovés PM, Fernández S, Rodríguez M, Pérez-Landaluce J, Patterson AM.

Int J Sport Nutr Exerc Metab. 2000 Jun;10(2):182-98. doi: 10.1123/ijsnem.10.2.182.PMID: 10928827 

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1998

 

Macronutrients intake of top level cyclists during continuous competition--change in the feeding pattern.

García-Rovés PM, Terrados N, Fernández SF, Patterson AM.

Int J Sports Med. 1998 Jan;19(1):61-7. doi: 10.1055/s-2007-971882.PMID: 9506803