The laboratory on “Metabolism and Mitochondrial function in Physiology and Disease " (MMFPD) is focused on studying the metabolic implications of chronic diseases such as Obesity, Diabetes, and Cancer. This unit is an association of four independent groups at the University of Barcelona; the group led by Dr. Jose C. Perales, focusing on “Metabolism and Mitochondrial Physiology”, the laboratory of “Integrative Physiology and Energy Metabolism” led by Dr. Pablo Garcia-Rovés, and the newly established “Cancer metabolism lab" led by Dr. Andrés Méndez-Lucas
and "Childhood obesity lab" led by José Carlos Jiménez Chillarón.

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José Carlos
Perales Lab

Pablo M.

García-Rovés Lab

José Carlos Jiménez Chillaron Lab

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Andrés Méndez Lucas Lab

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The group has long-standing recognition in their respective areas of expertise, that include: (i) gene delivery of DNA and siRNA to the liver and other tissues, (ii) molecular biology and metabolism of cancer and diabetes-target genes either overexpressed or silenced in vivo and in vitro, (iii) mechanisms of action of life-style intervention, drugs and metabolites in vivo and in vitro, (iv) the analysis of mitochondrial function, and (v) the application of genetics and stable isotope-based metabolomics approaches to investigate the metabolism of tumours in vivo .

Members

Principal Investigators

JCP 93 402 4295

PMG-R 93 402 4295
AML 93 402 4267

JCJC 93 402 4267

Team. Telf 93 403 7167

Dr Pau Gama

Dr Flavio Palmieri

Dr Marcela Parra-Vargas

Lidia de Benito Gómez

María Tormo Fabios

Marta Mourin Fernàndez

Ivonne Palacios Marín

Manuel Macías Herranz

Anna Bataller Bertolin

Kawtar Khatbane

Selected Publications

Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells

Petra Hyroššová, Marc Aragó, Cristina Muñoz-Pinedo, Francesc Viñals, Pablo M García-Rovés, Carmen Escolano, Andrés Méndez-Lucas, Jose C Perales

Cell Death and Disease (2022) 13:730 ; https://doi.org/10.1038/s41419-022-05177-x

Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

Alba Gonzalez-Franquesa, PauGama-Perez, Marta Kulis, Karolina Szczepanowska, Norma Dahdah, Sonia Moreno-Gomez, Ana Latorre-Pellicer, Rebeca Fernández-Ruiz, Antoni Aguilar-Mogas, Anne Hoffman, Erika Monelli, Sara Samino, Joan Miró-Blanch, Gregor Oemer, XavierDuran, Estrella Sanchez-Rebordelo, Marc Schneebergerg, Merce Obach, Joel Montane, Giancarlo Castellano, Vicente Chapaprieta, Lourdes Navarro, Ignacio Prieto, Carlos Castaño, Anna Novials, Ramon Gomis, Maria Monsalve, Marc Claret, Mariona Graupera, Guadalupe Soria, Joan Vendrell, Sonia Fernandez-Veledo, Jose Antonio Enríquez, Angel Carracedo, José Carlos Perales, Rubén Nogueiras, Laura Herrero, Markus A. Keller, Oscar Yanes, Marta Sales-Pardo, Roger Guimerà, Pablo M.Garcia-Roves.

Redox Biology Volume 54, August 2022, 102353. https://doi.org/10.1016/j.redox.2022.102353

Obesity causes irreversible mitochondria failure in visceral adipose tissue despite successful anti-obesogenic lifestyle-based interventions

Alba Gonzalez-Franquesa, Pau Gama-Perez, Marta Kulis, Norma Dahdah, Sonia Moreno-Gomez, Ana Latorre Pellicer, Rebeca Fernández-Ruiz, Antoni Aguilar-Mogas, Erika Monelli, Sara Samino, Joan Miró, Gregor Oemer, Xavier Duran, Estrella Sanchez-Rebordelo, Marc Schneeberger, Merce Obach, Joel Montane, Giancarlo Castellano, Vicente Chapaprieta, Lourdes Navarro, Ignacio Prieto, Carlos Castaño, Anna Novials, Ramon Gomis, Maria Monsalve, Marc Claret, Mariona Graupera, Guadalupe Soria, Joan Vendrell, Sonia Fernandez-Veledo, Jose Antonio Enríquez, Angel Carracedo, José Carlos Perales, Rubén Nogueiras, Laura Herrero, Markus A. Keller, Oscar Yanes, Marta Sales-Pardo, Roger Guimerà, José Ignacio Martín-Subero, Pablo M. Garcia-Roves

bioRxiv 2020. 07.08.194167; doi: https://doi.org/10.1101/2020.07.08.194167

PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner.

Hyroššová P, Aragó M, Moreno-Felici J, Fu X, Mendez-Lucas A, García-Rovés PM, Burgess S, Figueras A, Viñals F, Perales JC. Cancer Metab. 2021 Jan 7;9(1):1. doi: 10.1186/s40170-020-00236-3.PMID: 33413684 Free PMC article.

Identifying strategies to target the metabolic flexibility of tumours.

Méndez-Lucas A, Lin W, Driscoll PC, Legrave N, Novellasdemunt L, Xie C, Charles M, Wilson Z, Jones NP, Rayport S, Rodríguez-Justo M, Li V, MacRae JI, Hay N, Chen X, Yuneva M.

Nature Metab. 2020 Apr;2(4):335-350. doi: 10.1038/s42255-020-0195-8. Epub 2020 Apr 21.PMID: 32694609 Free PMC article.

Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M.

Aragó M, Moreno-Felici J, Abás S, Rodríguez-Arévalo S, Hyroššová P, Figueras A, Viñals F, Pérez B, Loza MI, Brea J, Latorre P, Carrodeguas JA, García-Rovés PM, Galdeano C, Ginex T, Luque FJ, Escolano C, Perales JC.

Biomed Pharmacother. 2020 Jan;121:109601. doi: 10.1016/j.biopha.2019.109601. Epub 2019 Nov 15.PMID: 31739159

Phosphoenolpyruvate from Glycolysis and PEPCK Regulate Cancer Cell Fate by Altering Cytosolic Ca2.

Moreno-Felici J, Hyroššová P, Aragó M, Rodríguez-Arévalo S, García-Rovés PM, Escolano C, Perales JC.

Cells. 2019 Dec 19;9(1):18. doi: 10.3390/cells9010018. PMID: 31861674

Other publications