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Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer

Peter Kreuzaler, Paolo Inglese, Avinash Ghanate, Ersa Gjelaj, Vincen Wu, Yulia Panina, Andrés Méndez-Lucas, Catherine MacLachlan, Neill Patani, Catherine B. Hubert, Helen Huang, Gina Greenidge, Oscar M. Rueda, Adam J. Taylor, Evdoxia Karali, Emine Kazanc, Amy Spicer, Alex Dexter, Wei Lin, Daria Thompson, Mariana Silva Dos Santos, Enrica Calvani, Nathalie Legrave, James K. Ellis, Wendy Greenwood, Mary Green, Emma Nye, Emma Still, CRUK Rosetta Grand Challenge Consortium, Simon Barry, Richard J. A. Goodwin, Alejandra Bruna, Carlos Caldas, James MacRae, Luiz Pedro Sório de Carvalho, George Poulogiannis, Greg McMahon, Zoltan Takats, Josephine Bunch & Mariia Yuneva

Nature Metabolism. volume 5, pages1870–1886 (2023)

 

PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner.

Hyroššová P, Aragó M, Moreno-Felici J, Fu X, Mendez-Lucas A, García-Rovés PM, Burgess S, Figueras A, Viñals F, Perales JC.

Cancer Metab. 2021 Jan 7;9(1):1. doi: 10.1186/s40170-020-00236-3.PMID: 33413684 

 

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Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes.

Sellers K, Allen TD, Bousamra M 2nd, Tan J, Méndez-Lucas A, Lin W, Bah N, Chernyavskaya Y, MacRae JI, Higashi RM, Lane AN, Fan TW, Yuneva MO.

Brittish Journal of Cancer. 2019 Jul;121(1):51-64. doi: 10.1038/s41416-019-0464-z. Epub 2019 May 22.PMID: 31114017 

 

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Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.

Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM.

Nature. 2019 Feb;566(7744):403-406. doi: 10.1038/s41586-019-0904-1. Epub 2019 Feb 6.PMID: 30728499 

 

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PEPCK-C reexpression in the liver counters neonatal hypoglycemia in Pck1 del/del mice, unmasking role in non-gluconeogenic tissues.

Semakova J, Hyroššová P, Méndez-Lucas A, Cutz E, Bermudez J, Burgess S, Alcántara S, Perales JC.

J Physiol Biochem. 2017 Feb;73(1):89-98. doi: 10.1007/s13105-016-0528-y. Epub 2016 Oct 26.PMID: 27785616

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p38α function in osteoblasts influences adipose tissue homeostasis.

Rodríguez-Carballo E, Gámez B, Méndez-Lucas A, Sánchez-Freutrie M, Zorzano A, Bartrons R, Alcántara S, Perales JC, Ventura F

FASEB J. 2015 Apr;29(4):1414-25. doi: 10.1096/fj.14-261891. Epub 2014 Dec 30.PMID: 25550462

 

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A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis.

Santana-Codina N, Carretero R, Sanz-Pamplona R, Cabrera T, Guney E, Oliva B, Clezardin P, Olarte OE, Loza-Alvarez P, Méndez-Lucas A, Perales JC, Sierra A.

Mol Cell Proteomics. 2013 Aug;12(8):2111-25. doi: 10.1074/mcp.M112.022772. Epub 2013 Apr 26.PMID: 23625662 Free PMC article.

 

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Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids.

Novellasdemunt L, Tato I, Navarro-Sabate A, Ruiz-Meana M, Méndez-Lucas A, Perales JC, Garcia-Dorado D, Ventura F,

Bartrons R, Rosa JL.J

Biol Chem. 2013 Apr 12;288(15):10640-51. doi: 10.1074/jbc.M113.455998. Epub 2013 Mar 2.PMID: 23457334 

 

 

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.

Satapati S, Sunny NE, Kucejova B, Fu X, He TT, Méndez-Lucas A, Shelton JM, Perales JC, Browning JD, Burgess SC.

J Lipid Res. 2012 Jun;53(6):1080-92. doi: 10.1194/jlr.M023382. Epub 2012 Apr 9.PMID: 22493093 

 

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Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase.

Vidal-Alabró A, Gómez-Valadés AG, Méndez-Lucas A, Llorens J, Bartrons R, Bermúdez J, Perales JC.

Int J Endocrinol. 2011;2011:707928. doi: 10.1155/2011/707928. Epub 2011 Dec 13.PMID: 22194744 

 

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Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice.

Gómez-Valadés AG, Méndez-Lucas A, Vidal-Alabró A, Blasco FX, Chillon M, Bartrons R, Bermúdez J, Perales JC.

Diabetes. 2008 Aug;57(8):2199-210. doi: 10.2337/db07-1087. Epub 2008 Apr 28.PMID: 18443203