PUBLICATIONS
2016-2020
PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner.
Hyroššová P, Aragó M, Moreno-Felici J, Fu X, Mendez-Lucas A, García-Rovés PM, Burgess S, Figueras A, Viñals F, Perales JC.
Cancer Metab. 2021 Jan 7;9(1):1. doi: 10.1186/s40170-020-00236-3.
PMID: 33413684 Free PMC article.
Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors.
Lahiguera Á, Hyroššová P, Figueras A, Garzón D, Moreno R, Soto-Cerrato V, McNeish I, Serra V, Lazaro C, Barretina P, Brunet J, Menéndez J, Matias-Guiu X, Vidal A, Villanueva A, Taylor-Harding B, Tanaka H, Orsulic S, Junza A, Yanes O, Muñoz-Pinedo C, Palomero L, Pujana MÀ, Perales JC, Viñals F.
EMBO Mol Med. 2020 Jun 8;12(6):e11217. doi: 10.15252/emmm.201911217. Epub 2020 May 13.
PMID: 32400970 Free PMC article.
Phosphoenolpyruvate from Glycolysis and PEPCK Regulate Cancer Cell Fate by Altering Cytosolic Ca2.
Moreno-Felici J, Hyroššová P, Aragó M, Rodríguez-Arévalo S, García-Rovés PM, Escolano C, Perales JC.
Cells. 2019 Dec 19;9(1):18. doi: 10.3390/cells9010018.
PMID: 31861674 Free PMC article.
Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M.
Aragó M, Moreno-Felici J, Abás S, Rodríguez-Arévalo S, Hyroššová P, Figueras A, Viñals F, Pérez B, Loza MI, Brea J, Latorre P, Carrodeguas JA, García-Rovés PM, Galdeano C, Ginex T, Luque FJ, Escolano C, Perales JC.
Biomed Pharmacother. 2020 Jan;121:109601. doi: 10.1016/j.biopha.2019.109601. Epub 2019 Nov 15.
PMID: 31739159 Free article.
Intestinal Inflammation Modulates the Epithelial Response to Butyrate in Patients With Inflammatory Bowel Disease.
Ferrer-Picón E, Dotti I, Corraliza AM, Mayorgas A, Esteller M, Perales JC, Ricart E, Masamunt MC, Carrasco A, Tristán E, Esteve M, Salas A.
Inflamm Bowel Dis. 2020 Jan 1;26(1):43-55. doi: 10.1093/ibd/izz119.
PMID: 31211831 Free PMC article.
Exploring the direct or inverse association of physical activity with behavioral addictions and other self-regulation problems.
Cardol CK, Escamilla CI, Gebhardt WA, Perales JC.
Adicciones. 2019 Jan 1;31(1):18-32. doi: 10.20882/adicciones.926.
PMID: 30059584 Free article. English, Spanish.
Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism.
Soukupova J, Malfettone A, Hyroššová P, Hernández-Alvarez MI, Peñuelas-Haro I, Bertran E, Junza A, Capellades J, Giannelli G, Yanes O, Zorzano A, Perales JC, Fabregat I.
Sci Rep. 2017 Oct 2;7(1):12486. doi: 10.1038/s41598-017-12837-y.
PMID: 28970582 Free PMC article.
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PEPCK-C reexpression in the liver counters neonatal hypoglycemia in Pck1 del/del mice, unmasking role in non-gluconeogenic tissues.
Semakova J, Hyroššová P, Méndez-Lucas A, Cutz E, Bermudez J, Burgess S, Alcántara S, Perales JC.
J Physiol Biochem. 2017 Feb;73(1):89-98. doi: 10.1007/s13105-016-0528-y. Epub 2016 Oct 26.
PMID: 27785616
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2010 - 2015
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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM.
Cell. 2015 Sep 10;162(6):1217-28. doi: 10.1016/j.cell.2015.08.012. Epub 2015 Aug 27.
PMID: 26321681 Free PMC article.
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p38α function in osteoblasts influences adipose tissue homeostasis.
Rodríguez-Carballo E, Gámez B, Méndez-Lucas A, Sánchez-Freutrie M, Zorzano A, Bartrons R, Alcántara S, Perales JC, Ventura F.
FASEB J. 2015 Apr;29(4):1414-25. doi: 10.1096/fj.14-261891. Epub 2014 Dec 30.
PMID: 25550462
Neuronal Progenitor Maintenance Requires Lactate Metabolism and PEPCK-M-Directed Cataplerosis.
Álvarez Z, Hyroššová P, Perales JC, Alcántara S.
Cereb Cortex. 2016 Mar;26(3):1046-58. doi: 10.1093/cercor/bhu281. Epub 2014 Dec 1.
PMID: 25452568
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability.
Méndez-Lucas A, Hyroššová P, Novellasdemunt L, Viñals F, Perales JC.
J Biol Chem. 2014 Aug 8;289(32):22090-102. doi: 10.1074/jbc.M114.566927. Epub 2014 Jun 27.
PMID: 24973213 Free PMC article.
A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.
Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S, Vidal A, Sanjuan X, Martinez-Balibrea E, Viñals F, Perales JC, Bramsem JB, Ørntoft TF, Andersen CL, Tabernero J, McDermott U, Boxer MB, Vander Heiden MG, Albar JP, Esteller M.
Nat Commun. 2014 Apr 3;5:3608. doi: 10.1038/ncomms4608.
PMID: 24699711 Free PMC article.
Functional characterization of the human mariner transposon Hsmar2.
Gil E, Bosch A, Lampe D, Lizcano JM, Perales JC, Danos O, Chillon M.
PLoS One. 2013 Sep 11;8(9):e73227. doi: 10.1371/journal.pone.0073227. eCollection 2013.
PMID: 24039890 Free PMC article.
Short-fiber protein of ad40 confers enteric tropism and protection against acidic gastrointestinal conditions.
Rodríguez E, Romero C, Río A, Miralles M, Raventós A, Planells L, Burgueño JF, Hamada H, Perales JC, Bosch A, Gassull MA, Fernández E, Chillon M.
Hum Gene Ther Methods. 2013 Aug;24(4):195-204. doi: 10.1089/hgtb.2012.096. Epub 2013 Jun 27.
PMID: 23746215
A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis.
Santana-Codina N, Carretero R, Sanz-Pamplona R, Cabrera T, Guney E, Oliva B, Clezardin P, Olarte OE, Loza-Alvarez P, Méndez-Lucas A, Perales JC, Sierra A.
Mol Cell Proteomics. 2013 Aug;12(8):2111-25. doi: 10.1074/mcp.M112.022772. Epub 2013 Apr 26.
PMID: 23625662 Free PMC article.
PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis.
Méndez-Lucas A, Duarte JA, Sunny NE, Satapati S, He T, Fu X, Bermúdez J, Burgess SC, Perales JC.
J Hepatol. 2013 Jul;59(1):105-13. doi: 10.1016/j.jhep.2013.02.020. Epub 2013 Mar 4.
PMID: 23466304 Free PMC article.
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Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids.
Novellasdemunt L, Tato I, Navarro-Sabate A, Ruiz-Meana M, Méndez-Lucas A, Perales JC, Garcia-Dorado D, Ventura F, Bartrons R, Rosa JL.
J Biol Chem. 2013 Apr 12;288(15):10640-51. doi: 10.1074/jbc.M113.455998. Epub 2013 Mar 2.
PMID: 23457334 Free PMC article.
Specific Jak3 Downregulation in Lymphocytes Impairs γc Cytokine Signal Transduction and Alleviates Antigen-driven Inflammation In Vivo.
Gómez-Valadés AG, Llamas M, Blanch S, Perales JC, Román J, Gómez-Casajús L, Mascaró C.
Mol Ther Nucleic Acids. 2012 Sep 4;1(9):e42. doi: 10.1038/mtna.2012.37.
PMID: 23344234 Free PMC article.
The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche.
Álvarez Z, Mateos-Timoneda MA, Hyroššová P, Castaño O, Planell JA, Perales JC, Engel E, Alcántara S.
Biomaterials. 2013 Mar;34(9):2221-33. doi: 10.1016/j.biomaterials.2012.12.001. Epub 2012 Dec 28.
PMID: 23276659
Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP/PS1 mice used as a model of familial Alzheimer's disease.
Aso E, Semakova J, Joda L, Semak V, Halbaut L, Calpena A, Escolano C, Perales JC, Ferrer I.
Curr Alzheimer Res. 2013 Mar;10(3):290-7. doi: 10.2174/15672050112099990128.
PMID: 23131121
New antidepressant strategy based on acute siRNA silencing of 5-HT1A autoreceptors.
Bortolozzi A, Castañé A, Semakova J, Santana N, Alvarado G, Cortés R, Ferrés-Coy A, Fernández G, Carmona MC, Toth M, Perales JC, Montefeltro A, Artigas F.
Mol Psychiatry. 2012 Jun;17(6):567. doi: 10.1038/mp.2012.52.
PMID: 22617870 No abstract available.
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.
Satapati S, Sunny NE, Kucejova B, Fu X, He TT, Méndez-Lucas A, Shelton JM, Perales JC, Browning JD, Burgess SC.
J Lipid Res. 2012 Jun;53(6):1080-92. doi: 10.1194/jlr.M023382. Epub 2012 Apr 9.
PMID: 22493093 Free PMC article.
Synthesis and in vitro inhibition properties of siRNA conjugates carrying acridine and quindoline moieties.
Aviñó A, Ocampo SM, Perales JC, Eritja R.
Chem Biodivers. 2012 Mar;9(3):557-66. doi: 10.1002/cbdv.201100321.
PMID: 22422523
Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase.
Vidal-Alabró A, Gómez-Valadés AG, Méndez-Lucas A, Llorens J, Bartrons R, Bermúdez J, Perales JC.
Int J Endocrinol. 2011;2011:707928. doi: 10.1155/2011/707928. Epub 2011 Dec 13.
PMID: 22194744 Free PMC article.
Functionally enhanced siRNA targeting TNFα attenuates DSS-induced colitis and TLR-mediated immunostimulation in mice.
Ocampo SM, Romero C, Aviñó A, Burgueño J, Gassull MA, Bermúdez J, Eritja R, Fernandez E, Perales JC.
Mol Ther. 2012 Feb;20(2):382-90. doi: 10.1038/mt.2011.236. Epub 2011 Nov 1.
PMID: 22044934 Free PMC article.
Neuropsychological profiling of impulsivity and compulsivity in cocaine dependent individuals.
Fernández-Serrano MJ, Perales JC, Moreno-López L, Pérez-García M, Verdejo-García A.
Psychopharmacology (Berl). 2012 Jan;219(2):673-83. doi: 10.1007/s00213-011-2485-z. Epub 2011 Sep 16.
PMID: 21922168
Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects.
Bortolozzi A, Castañé A, Semakova J, Santana N, Alvarado G, Cortés R, Ferrés-Coy A, Fernández G, Carmona MC, Toth M, Perales JC, Montefeltro A, Artigas F.
Mol Psychiatry. 2012 Jun;17(6):612-23. doi: 10.1038/mp.2011.92. Epub 2011 Aug 2.
PMID: 21808255 Free article.
Branched RNA: A New Architecture for RNA Interference.
Aviñó A, Ocampo SM, Perales JC, Eritja R.
J Nucleic Acids. 2011 Mar 6;2011:586935. doi: 10.4061/2011/586935.
PMID: 21461398 Free PMC article.
Effect of north bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification.
Terrazas M, Ocampo SM, Perales JC, Marquez VE, Eritja R.
Chembiochem. 2011 May 2;12(7):1056-65. doi: 10.1002/cbic.201000791. Epub 2011 Mar 30.
PMID: 21452187
Synthesis of lipid-oligonucleotide conjugates for RNA interference studies.
Grijalvo S, Ocampo SM, Perales JC, Eritja R.
Chem Biodivers. 2011 Feb;8(2):287-99. doi: 10.1002/cbdv.201000274.
PMID: 21337501
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Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations.
Aviñó A, Ocampo SM, Lucas R, Reina JJ, Morales JC, Perales JC, Eritja R.
Mol Divers. 2011 Aug;15(3):751-7. doi: 10.1007/s11030-011-9305-6. Epub 2011 Jan 26.
PMID: 21267652
Synthesis of oligonucleotides carrying amino lipid groups at the 3'-end for RNA interference studies.
Grijalvo S, Ocampo SM, Perales JC, Eritja R.
J Org Chem. 2010 Oct 15;75(20):6806-13. doi: 10.1021/jo101143j.
PMID: 20863084
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2000 - 2010
Reduced milk triglycerides in mice lacking phosphoenolpyruvate carboxykinase in mammary gland adipocytes and white adipose tissue contribute to the development of insulin resistance in pups.
Hsieh CW, Millward CA, DeSantis D, Pisano S, Machova J, Perales JC, Croniger CM.
J Nutr. 2009 Dec;139(12):2257-65. doi: 10.3945/jn.109.113092. Epub 2009 Oct 7.
PMID: 19812223 Free PMC article.
Pfkfb3 is transcriptionally upregulated in diabetic mouse liver through proliferative signals.
Duran J, Obach M, Navarro-Sabate A, Manzano A, Gómez M, Rosa JL, Ventura F, Perales JC, Bartrons R.
FEBS J. 2009 Aug;276(16):4555-68. doi: 10.1111/j.1742-4658.2009.07161.x. Epub 2009 Jul 18.
PMID: 19645723 Free article.
Fructose 1,6-bisphosphate reduced TNF-alpha-induced apoptosis in galactosamine sensitized rat hepatocytes through activation of nitric oxide and cGMP production.
Calafell R, Boada J, Santidrian AF, Gil J, Roig T, Perales JC, Bermudez J.
Eur J Pharmacol. 2009 May 21;610(1-3):128-33. doi: 10.1016/j.ejphar.2009.03.044. Epub 2009 Mar 24.
PMID: 19324037
Stepwise synthesis of RNA conjugates carrying peptide sequences for RNA interference studies.
Aviñó A, Ocampo SM, Caminal C, Perales JC, Eritja R.
Mol Divers. 2009 Aug;13(3):287-93. doi: 10.1007/s11030-009-9110-7. Epub 2009 Feb 3.
PMID: 19189224
Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice.
Gómez-Valadés AG, Méndez-Lucas A, Vidal-Alabró A, Blasco FX, Chillon M, Bartrons R, Bermúdez J, Perales JC.
Diabetes. 2008 Aug;57(8):2199-210. doi: 10.2337/db07-1087. Epub 2008 Apr 28.
PMID: 18443203 Free PMC article.
Characterization of a new liver- and kidney-specific pfkfb3 isozyme that is downregulated by cell proliferation and dedifferentiation.
Duran J, Gómez M, Navarro-Sabate A, Riera-Sans L, Obach M, Manzano A, Perales JC, Bartrons R.
Biochem Biophys Res Commun. 2008 Mar 21;367(4):748-54. doi: 10.1016/j.bbrc.2008.01.005. Epub 2008 Jan 10.
PMID: 18191036
Overexpression of ubiquitous 6-phosphofructo-2-kinase in the liver of transgenic mice results in weight gain.
Duran J, Navarro-Sabate A, Pujol A, Perales JC, Manzano A, Obach M, Gómez M, Bartrons R.
Biochem Biophys Res Commun. 2008 Jan 11;365(2):291-7. doi: 10.1016/j.bbrc.2007.10.181. Epub 2007 Nov 6.
PMID: 17991424
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PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells.
Calvo MN, Bartrons R, Castaño E, Perales JC, Navarro-Sabaté A, Manzano A.
FEBS Lett. 2006 May 29;580(13):3308-14. doi: 10.1016/j.febslet.2006.04.093. Epub 2006 May 8.
PMID: 16698023 Free article.
Fructose 1,6-bisphosphate prevented endotoxemia, macrophage activation, and liver injury induced by D-galactosamine in rats.
Cuesta E, Boada J, Calafell R, Perales JC, Roig T, Bermudez J.
Crit Care Med. 2006 Mar;34(3):807-14. doi: 10.1097/01.ccm.0000202016.60856.03.
PMID: 16521276
Overcoming diabetes-induced hyperglycemia through inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP) with RNAi.
Gómez-Valadés AG, Vidal-Alabró A, Molas M, Boada J, Bermúdez J, Bartrons R, Perales JC.
Mol Ther. 2006 Feb;13(2):401-10. doi: 10.1016/j.ymthe.2005.08.026. Epub 2005 Nov 3.
PMID: 16271515 Free article.
Aspirin inhibits NF-kappaB activation in a glycolysis-depleted lung epithelial cell line.
Cuesta E, Boada J, Perales JC, Roig T, Bermudez J.
Eur J Pharmacol. 2005 Jul 11;517(3):158-64. doi: 10.1016/j.ejphar.2005.05.024.
PMID: 15987633
Assessment of a dual regulatory role for NO in liver regeneration after partial hepatectomy: protection against apoptosis and retardation of hepatocyte proliferation.
Zeini M, Hortelano S, Través PG, Gómez-Valadés AG, Pujol A, Perales JC, Bartrons R, Boscá L.
FASEB J. 2005 Jun;19(8):995-7. doi: 10.1096/fj.04-3233fje. Epub 2005 Mar 23.
PMID: 15788446
Copolymers of poly-L-lysine with serine and tryptophan form stable DNA vectors: implications for receptor-mediated gene transfer.
Gómez-Valadés AG, Molas M, Vidal-Alabró A, Bermúdez J, Bartrons R, Perales JC.
J Control Release. 2005 Jan 20;102(1):277-91. doi: 10.1016/j.jconrel.2004.09.020.
PMID: 15653152
Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region.
Gómez M, Manzano A, Navarro-Sabaté A, Duran J, Obach M, Perales JC, Bartrons R.
FEBS Lett. 2005 Jan 17;579(2):357-62. doi: 10.1016/j.febslet.2004.11.096.
PMID: 15642344 Free article.
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6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia.
Obach M, Navarro-Sabaté A, Caro J, Kong X, Duran J, Gómez M, Perales JC, Ventura F, Rosa JL, Bartrons R.
J Biol Chem. 2004 Dec 17;279(51):53562-70. doi: 10.1074/jbc.M406096200. Epub 2004 Oct 5.
PMID: 15466858 Free article.
Glutathione content and adaptation to endogenously induced energy depletion in Mv1Lu cells.
Boada J, Cuesta E, Perales JC, Roig T, Bermudez J.
Free Radic Biol Med. 2004 Jun 15;36(12):1555-65. doi: 10.1016/j.freeradbiomed.2004.04.009.
PMID: 15182857
Receptor-mediated gene transfer vectors: progress towards genetic pharmaceuticals.
Molas M, Gómez-Valadés AG, Vidal-Alabró A, Miguel-Turu M, Bermudez J, Bartrons R, Perales JC.
Curr Gene Ther. 2003 Oct;3(5):468-85. doi: 10.2174/1566523034578195.
PMID: 14529352 Review.
Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation.
Riera L, Obach M, Navarro-Sabaté A, Duran J, Perales JC, Viñals F, Rosa JL, Ventura F, Bartrons R.
FEBS Lett. 2003 Aug 28;550(1-3):23-9. doi: 10.1016/s0014-5793(03)00808-1.
PMID: 12935880 Free article.
Single-stranded DNA condensed with poly-L-lysine results in nanometric particles that are significantly smaller, more stable in physiological ionic strength fluids and afford higher efficiency of gene delivery than their double-stranded counterparts.
Molas M, Bartrons R, Perales JC.
Biochim Biophys Acta. 2002 Aug 15;1572(1):37-44. doi: 10.1016/s0304-4165(02)00276-3.
PMID: 12204331
The combination of ischemic preconditioning and liver Bcl-2 overexpression is a suitable strategy to prevent liver and lung damage after hepatic ischemia-reperfusion.
Peralta C, Perales JC, Bartrons R, Mitchell C, Gilgenkrantz H, Xaus C, Prats N, Fernández L, Gelpí E, Panés J, Roselló-Catafau J.
Am J Pathol. 2002 Jun;160(6):2111-22. doi: 10.1016/S0002-9440(10)61160-1.
PMID: 12057915 Free PMC article.
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Insulin induces PFKFB3 gene expression in HT29 human colon adenocarcinoma cells.
Riera L, Manzano A, Navarro-Sabaté A, Perales JC, Bartrons R.
Biochim Biophys Acta. 2002 Apr 3;1589(2):89-92. doi: 10.1016/s0167-4889(02)00169-6.
PMID: 12007784 Free article.
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Biological properties of poly-L-lysine-DNA complexes generated by cooperative binding of the polycation.
Liu G, Molas M, Grossmann GA, Pasumarthy M, Perales JC, Cooper MJ, Hanson RW.
J Biol Chem. 2001 Sep 14;276(37):34379-87. doi: 10.1074/jbc.M105250200. Epub 2001 Jul 3.
PMID: 11438546 Free article.
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1993 - 2000
Transfer of the human Alpha1-antitrypsin gene into pulmonary macrophages in vivo.
Ferkol T, Mularo F, Hilliard J, Lodish S, Perales JC, Ziady A, Konstan M.
Am J Respir Cell Mol Biol. 1998 May;18(5):591-601. doi: 10.1165/ajrcmb.18.5.2874.
PMID: 9569229
Gene transfer into hepatoma cell lines via the serpin enzyme complex receptor.
Ziady AG, Perales JC, Ferkol T, Gerken T, Beegen H, Perlmutter DH, Davis PB.
Am J Physiol. 1997 Aug;273(2 Pt 1):G545-52. doi: 10.1152/ajpgi.1997.273.2.G545.
PMID: 9277436 Free PMC article.
Safety-modified episomal vectors for human gene therapy.
Cooper MJ, Lippa M, Payne JM, Hatzivassiliou G, Reifenberg E, Fayazi B, Perales JC, Morrison LJ, Templeton D, Piekarz RL, Tan J.
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6450-5. doi: 10.1073/pnas.94.12.6450.
PMID: 9177238 Free PMC article.
Biochemical and functional characterization of DNA complexes capable of targeting genes to hepatocytes via the asialoglycoprotein receptor.
Perales JC, Grossmann GA, Molas M, Liu G, Ferkol T, Harpst J, Oda H, Hanson RW.
J Biol Chem. 1997 Mar 14;272(11):7398-407. doi: 10.1074/jbc.272.11.7398.
PMID: 9054440 Free article.
Axon-mediated gene transfer of retinal ganglion cells in vivo.
Garcia-Valenzuela E, Rayanade R, Perales JC, Davidson CA, Hanson RW, Sharma SC.
J Neurobiol. 1997 Jan;32(1):111-22. doi: 10.1002/(sici)1097-4695(199701)32:1<111::aid-neu10>3.0.co;2-n.
PMID: 8989667
Immunologic responses to gene transfer into mice via the polymeric immunoglobulin receptor.
Ferkol T, Pellicena-Palle A, Eckman E, Perales JC, Trzaska T, Tosi M, Redline R, Davis PB.
Gene Ther. 1996 Aug;3(8):669-78.
PMID: 8854092
Receptor-mediated gene transfer into macrophages.
Ferkol T, Perales JC, Mularo F, Hanson RW.
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):101-5. doi: 10.1073/pnas.93.1.101.
PMID: 8552583 Free PMC article.
Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor.
Ferkol T, Perales JC, Eckman E, Kaetzel CS, Hanson RW, Davis PB.
J Clin Invest. 1995 Feb;95(2):493-502. doi: 10.1172/JCI117690.
PMID: 7860731 Free PMC article.
An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes.
Perales JC, Ferkol T, Molas M, Hanson RW.
Eur J Biochem. 1994 Dec 1;226(2):255-66. doi: 10.1111/j.1432-1033.1994.tb20049.x.
PMID: 8001543 Free article. Review.
Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake.
Perales JC, Ferkol T, Beegen H, Ratnoff OD, Hanson RW.
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4086-90. doi: 10.1073/pnas.91.9.4086.
PMID: 8171039 Free PMC article.
Expression of the neomycin-resistance (neo) gene induces alterations in gene expression and metabolism.
Valera A, Perales JC, Hatzoglou M, Bosch F.
Hum Gene Ther. 1994 Apr;5(4):449-56. doi: 10.1089/hum.1994.5.4-449.
PMID: 7914094
Regulation of the phosphoenolpyruvate carboxykinase/human factor IX gene introduced into the livers of adult rats by receptor-mediated gene transfer.
Ferkol T, Lindberg GL, Chen J, Perales JC, Crawford DR, Ratnoff OD, Hanson RW.
FASEB J. 1993 Aug;7(11):1081-91. doi: 10.1096/fasebj.7.11.8370479.
PMID: 8370479